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  • Bioinformatics, Biology, Life Sciences
    Abstract Zinc-dependent metallo-β-lactamases contribute to carbapenem resistance, motivating the search for molecules that engage their catalytic sites. This study developed an AlphaFold 3 (AF3)-guided workflow to design and prioritize 25-residue candidate peptide binders to VIM-2. The search objective combined predicted aligned error, burial of six specified receptor residues and balanced burial of two catalytic zinc […]
  • Health Sciences, Psychology
    Abstract Introduction: Adolescence is a critical period for cognitive and emotional growth. In the U.S., an estimated 38% of high school students report serious cognitive difficulties, and about 20% of adolescents have a diagnosed mental or behavioral health condition such as anxiety, both associated with poorer academic performance and psychosocial functioning. Because both problems are […]
  • Physical Sciences, Physics
    Abstract This study asks whether a simplified driven two level model can quantitatively reproduce coherent excitation dynamics of a localized photoactive transition, evaluated through agreement with analytical Rabi oscillations with an error threshold below 1%. A Python simulation using QuTip was developed to reproduce photoinduced excitation dynamics. This was then used to validate the characteristic […]
  • Computing, Data & AI, Data Science
    Abstract Automatic Identification Systems (AIS) generate millions of vessel positions per day, so training machine learning (ML) models on complete datasets is expensive. Prior AIS reduction work has evaluated trajectory simplification on downstream tasks; however, no reviewed study has compared multiple competing ping-level sampling strategies across multiple downstream ML tasks and anomaly-label definitions within one […]
  • Civil Engineering, Engineering
    Abstract Most levees in California are old structures, many of which were originally built in the 1800s and are now vulnerable to collapse. In response to growing concerns about their integrity, the state has issued a mandate requiring that levees in high-risk areas be upgraded by 2030. One of the primary threats to levee stability […]
  • Social Sciences, Social Sciences, Humanities & Policy
    Abstract This is a qualitative pilot study that explores the ways that Korean adolescents told and interpreted their schooling experiences across selective educational contexts in South Korea and the United States. Rather than treating the Korean and U.S. educational contexts as directly comparable national systems, this study places emphasis on three Korean students’ experiences in […]

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