Effects of Nitro-Oleic Acid on RAW-Blue™ Cell Activity

by David J Portnoy Abstract Chronic inflammatory disease affects millions of individuals around the world. Inflammation occurs when foreign bacteria bind to receptors on cell surfaces, thereby inducing macrophage activation. This series of actions leads to the release of pro-inflammatory molecules, like nitric oxide (NO), resulting in inflammation. A major driver of inflammatory responses is the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB). This study seeks to examine the interaction between OA-NO2 […]

In Silico Analysis and Docking Study on a Potential Wild-Type, Tumor Suppressor Protein P53 Activator using Thymoquinone

Ahnaf Khan Student, Thomas Jefferson High School for Science and Technology, Alexandria, Virginia ABSTRACT: p53 is a potent tumor suppressor protein that is frequently mutated or inactivated in almost 50% of all human cancers. These statistics, as well as essential functions of p53 in maintaining normal cell cycle and apoptosis, impose the urge to extend new methods for making p53 a target for new molecular-based therapies. The purpose of this study was to analyze the […]