In Silico Analysis and Docking Study on a Potential Wild-Type, Tumor Suppressor Protein P53 Activator using Thymoquinone

Ahnaf Khan Student, Thomas Jefferson High School for Science and Technology, Alexandria, Virginia ABSTRACT: p53 is a potent tumor suppressor protein that is frequently mutated or inactivated in almost 50% of all human cancers. These statistics, as well as essential functions of p53 in maintaining normal cell cycle and apoptosis, impose the urge to extend new methods for making p53 a target for new molecular-based therapies. The purpose of this study was to analyze the […]

Assessing the Development of Artificial Intelligence Technologies In Radiation Therapy and Targeting Irregular Masses

Eric Bear, Jessica Singh, and Michael Wahrman   ABSTRACT The purpose of this paper is to evaluate the use of artificial intelligence in the medical use of particle accelerators for both treatment (radiation therapy) and imaging. We will first discuss the implications of artificial intelligence (AI) on particle accelerators, starting with basic control mechanisms and then moving to complex systems such as neural networking. AI has the potential to increase efficiency and precision in all […]

A New Signaling Pathway in Diamond Blackfan Anemia

Sriya Kudaravalli Diamond Blackfan Anemia (DBA) is blood disease in which the bone marrow malfunctions and fails to make enough erythrocytes, or red blood cells. Inherited in an autosomal dominant pattern, DBA affects approximately five to seven million infants globally, and about half of the DBA patients possess physical abnormalities, such as microcephaly, hypertelorism, Ptosis, micrognathia, webbed neck, absent thumbs, cataracts, and glaucoma. In addition, affected patients have an increased risk of developing acute myeloid […]

Mela-NO-More: Fighting Cancer with Immunotherapy

Author:¬†Anika Markan Introduction: In 2017, approximately 87,110 new cases of ¬†melanoma will be diagnosed and about 9,730 people are expected to die of melanoma. For the past 30 years, the rates of melanoma have been rising (Key Statistics for Melanoma Skin Cancer 1). There are many new treatments being discovered to treat melanoma everyday. Among the most common cancer treatments are chemotherapy, radiation therapy, and surgery. Chemotherapy is a systemic therapy that targets growing cancer […]