Examining the Effect of TRIP13 Over Expression on Cancerous Aneuploidy

        This Research was completed with the University of Toledo Sanjay Jinka Anthony Wayne High School 2801 W Bancroft St, Toledo, OH 43606 ABSTRACT Nineteen million people are projected to have cancer by 2024 so understanding tumorigenesis is of foremost importance. Of solid tumors, 90 percent are aneuploid, signifying an abnormal number of chromosomes usually caused by malfunctioning mitotic checkpoints. TRIP13 AAA-ATPase is a crucial silencing protein in this checkpoint. Therefore, it was hypothesized that TRIP13 […]

Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]

A Three Year Study of an Isolated Brook Trout Population in the Eastern Adirondacks: Sustainability, Propagation and Genetics

Over the past several years changing weather patterns have led to costly and destructive storms that are damaging both environmentally and economically. In 2011, Hurricane Irene was an unusual storm because it struck the eastern Adirondack Mountains in New York. The Adirondack region mainly relies on tourists to make money and fishing is a large part of what draws people to this region. Three years ago, a study was started to explore the impact of […]

Shedding Light on Genomic Dark Matter: An Introduction to Long Noncoding RNA

Abstract While the central dogma of biology describes RNA’s role as a messenger to relay DNA code into protein production, not all RNA is directly involved in protein synthesis. Within the past few decades, largely due to the availability of whole-genome sequences and emerging RNA sequencing technologies, research has expanded to focus on RNA that does not code for proteins, or noncoding RNA. While scientists have known about noncoding RNAs (ncRNAs), such as ribosomal RNA […]

Twenty-first century genetics: power and responsibility

Of the relatively recent, notable advancements in the fields of medicine and biotechnology, many are connected to the study of genetics and genomics. Following Watson and Crick’s discovery of the DNA double helix, research on DNA and its implications in genetics and life escalated through the 1980s and 1990s to the epic, groundbreaking work of the Human Genome Project in 2003. Today, ten years later, genetic information plays a significant part in public health and […]