Ewing Sarcoma

Ewing Sarcoma by Mafalda von Alvensleben Ewing Sarcoma, though unbeknownst to most of the general population, is a type of pediatric cancer that affects the soft tissue or bone. Approximately 225 people in the United States are diagnosed with this disease each year, primarily those between the ages of ten and twenty, making it comprise about 1% of all pediatric cancers. Ewing Sarcoma is typically discovered via radio-imaging techniques and confirmed by a biopsy of the […]

A Prudent and Democratic Approach to Regulating CRISPR/Cas 9

By Daniel Cui Purpose The purpose of this study is to determine a judicious and egalitarian method of regulating the recently discovered CRISPR/Cas9 gene-editing biotechnology and determining some of the major themes in its relevant ethical, social, legal, and religious issues that could potentially have a major impact on humanity in the future. Conclusions were drawn based on the 1975 Asilomar Conference regarding recombinant DNA and analyzing the ethical, social, legal, and religious implications. Because […]

In Silico Analysis and Docking Study on a Potential Wild-Type, Tumor Suppressor Protein P53 Activator using Thymoquinone

Ahnaf Khan Student, Thomas Jefferson High School for Science and Technology, Alexandria, Virginia ABSTRACT: p53 is a potent tumor suppressor protein that is frequently mutated or inactivated in almost 50% of all human cancers. These statistics, as well as essential functions of p53 in maintaining normal cell cycle and apoptosis, impose the urge to extend new methods for making p53 a target for new molecular-based therapies. The purpose of this study was to analyze the […]

Examining the Effect of TRIP13 Over Expression on Cancerous Aneuploidy

        This Research was completed with the University of Toledo Sanjay Jinka Anthony Wayne High School 2801 W Bancroft St, Toledo, OH 43606 ABSTRACT Nineteen million people are projected to have cancer by 2024 so understanding tumorigenesis is of foremost importance. Of solid tumors, 90 percent are aneuploid, signifying an abnormal number of chromosomes usually caused by malfunctioning mitotic checkpoints. TRIP13 AAA-ATPase is a crucial silencing protein in this checkpoint. Therefore, it was hypothesized that TRIP13 […]

Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]