Effects of Nitro-Oleic Acid on RAW-Blue™ Cell Activity

by David J Portnoy Abstract Chronic inflammatory disease affects millions of individuals around the world. Inflammation occurs when foreign bacteria bind to receptors on cell surfaces, thereby inducing macrophage activation. This series of actions leads to the release of pro-inflammatory molecules, like nitric oxide (NO), resulting in inflammation. A major driver of inflammatory responses is the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB). This study seeks to examine the interaction between OA-NO2 […]

Ewing Sarcoma

Ewing Sarcoma by Mafalda von Alvensleben Ewing Sarcoma, though unbeknownst to most of the general population, is a type of pediatric cancer that affects the soft tissue or bone. Approximately 225 people in the United States are diagnosed with this disease each year, primarily those between the ages of ten and twenty, making it comprise about 1% of all pediatric cancers. Ewing Sarcoma is typically discovered via radio-imaging techniques and confirmed by a biopsy of the […]

Development of a Small Molecule C-X-C Chemokine Receptor Type 4 (CXCR4) Agonist

Authorship: Tiffany Ding*, Susriya Gangireddy*, Andrew Shum, Richard J. Miller** *These authors contributed equally **Corresponding author: r-miller10@northwestern.edu Student: Illinois Math and Science Academy, 1500 Sullivan Road, Aurora, IL Mentor: Northwestern University-Feinberg School of Medicine, 645 N Michigan Avenue, Suite 900, Chicago, IL Abstract: Activation of the C-X-C chemokine receptor type 4 (CXCR4) by its natural ligand stromal cell-derived factor 1 (SDF-1) is known to be involved in a number of vital physiological processes such as […]