Customized Chemotherapy Regime Based on Blood Vessels with Different Number of Stenosis

  Yifan Wang 1, Will Cao 2 1 Indian Springs School, 190 Woodward Drive, Indian Springs, AL 35124, USA E-mail: yifan.wang@indiansprings.org 2 Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA Email: yangxiaolu.cao@duke.edu Abstract Chemotherapy has been an effective approach to treat cancer; however, chemotherapy's effectiveness could be influenced by many unknown and often neglected factors. In this project, we build mathematical models in MATLAB to explain what impact will blood vessel with stenosis […]

Examining the Effect of TRIP13 Over Expression on Cancerous Aneuploidy

        This Research was completed with the University of Toledo Sanjay Jinka Anthony Wayne High School 2801 W Bancroft St, Toledo, OH 43606 ABSTRACT Nineteen million people are projected to have cancer by 2024 so understanding tumorigenesis is of foremost importance. Of solid tumors, 90 percent are aneuploid, signifying an abnormal number of chromosomes usually caused by malfunctioning mitotic checkpoints. TRIP13 AAA-ATPase is a crucial silencing protein in this checkpoint. Therefore, it was hypothesized that TRIP13 […]

Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]

Stem cells show potential for glioblastoma treatment

Changes in the Characteristics of AC133+ Stem Cells in Hypoxic U251 Glioblastoma Cell Microenvironment Abstract Angiogenesis, the formation of blood vessels, is a critical factor in brain cancer growth. Anti-angiogenic drugs block oxygen supply to the tumor by preventing blood vessel formation. Previous in vivo studies suggested a link between anti-angiogenic treatment and increased tumor growth post-remission. Our study attempts to examine the role of AC133+ stem cells in the glioblastoma microenvironment to understand tumor […]

The Fight Against Cancer

Message from the Editor: This article is undergoing final rounds of review. We would like to know your suggestions for the paper -- on research, writing, etc. We are including one of our reviewer's comments along with this paper. Share your suggestions in our new Forum. All of us, one time or another in our lives will be affected by cancer. Approximately 39% of us will get cancer at some time in our lives, and […]