Investigating ALS Associated Mutations on the FUS Gene

Investigating ALS Associated Mutations on the FUS Gene Author: Eesha Verma   Abstract In the Fused in Sarcoma (FUS) protein, amyotrophic lateral sclerosis (ALS) linked mutations cluster in the C-terminal nuclear localization sequence (NLS), a domain that binds to transportin- 1 (TNPO1) for import of FUS into the nucleus. This project was conducted to gain a better understanding of the structural and functional effects of mutations in the NLS domain. It was hypothesized that the […]

Detection of the KIT D816V gene mutation using chip-based Digital PCR Technology

Detection of the KIT D816V gene mutation using chip-based Digital PCR Technology Michelle Mai Century High School Rochester, MN 55906 Abstract The single point mutation of KIT D816V is the common genetic mutation of Systemic Mastocytosis (SM) and other cancers such as Acute Myelogenous Leukemia (AML) and gastrointestinal stromal tumors. Real-time allele-specific relative quantification is a common technique for detecting mutant allele vs. wild-type allele despite having well-known limitations. Examples of limitations include an inability […]

Implementation and Feasibility of Artificial Muscles in Prosthesis

Implementation and Feasibility of Artificial Muscles in Prosthesis by Brady Russell Abstract Artificial Muscles (electroactive polymers, dielectric elastomers, etc.) have been looked at for potential use in prosthesis and orthotics. The purpose of this research is to look at the feasibility of using these current technologies, especially in their respective ability for load bearing capacity and power consumption. My focus was on three types of artificial muscles: Peano-HASEL actuators, McKibben actuators, and dielectric elastomers. All of […]

Ewing Sarcoma

Ewing Sarcoma by Mafalda von Alvensleben Ewing Sarcoma, though unbeknownst to most of the general population, is a type of pediatric cancer that affects the soft tissue or bone. Approximately 225 people in the United States are diagnosed with this disease each year, primarily those between the ages of ten and twenty, making it comprise about 1% of all pediatric cancers. Ewing Sarcoma is typically discovered via radio-imaging techniques and confirmed by a biopsy of the […]

A Prudent and Democratic Approach to Regulating CRISPR/Cas 9

By Daniel Cui Purpose The purpose of this study is to determine a judicious and egalitarian method of regulating the recently discovered CRISPR/Cas9 gene-editing biotechnology and determining some of the major themes in its relevant ethical, social, legal, and religious issues that could potentially have a major impact on humanity in the future. Conclusions were drawn based on the 1975 Asilomar Conference regarding recombinant DNA and analyzing the ethical, social, legal, and religious implications. Because […]