Investigating ALS Associated Mutations on the FUS Gene

Investigating ALS Associated Mutations on the FUS Gene Author: Eesha Verma   Abstract In the Fused in Sarcoma (FUS) protein, amyotrophic lateral sclerosis (ALS) linked mutations cluster in the C-terminal nuclear localization sequence (NLS), a domain that binds to transportin- 1 (TNPO1) for import of FUS into the nucleus. This project was conducted to gain a better understanding of the structural and functional effects of mutations in the NLS domain. It was hypothesized that the […]