Unraveling Alzheimer's: The Effects of Tau on AB Protein Aggregation

Abstract Alzheimer’s is a neurodegenerative disease characterized by the formation of extracellular amyloid-beta (abeta or AB) plaques and intracellular tau plaques. This experiment explores whether the presence of normal tau-441 protein augments AB-42 aggregation. The concentration at which each protein self-aggregated was identified by creating aggregation curves. A control and experimental aliquot of AB/buffer and AB/tau respectively were then scanned at regular intervals to determine the rate amount of aggregation in each. The conclusion is […]

Identifying the Optimal Concentrations of Luminol and Sodium Carbonate in Aqueous Media for Sonoluminescence

Contents 1  Abstract 2  Introduction    3.1  Background Research    3.2  Purpose    3.3  Hypothesis 3  Procedure    4.1  Materials    4.2  Methods    4.3  Images of Experimental Setup and Brightest Solution 4  Results and Discussion    5.1  Lowess and Interpolant Models    5.2  Polynomial Models 5  Conclusion 6  Plans for Future Research 7  Acknowledgments 8  Appendix    8.1  MATLAB script    8.2  Mean, Sum, and Standard Deviation for All Solutions    8.3  Graph of Interpolant (Nearest Neighbor) Model    8.4  Images of Experimental Setup and Brightest […]

Secondary Structure Changes caused by ADAR Protein in the Development of ALS, Leukemia, and Schizophrenia

By Kavya Anjur Metea Valley High School, IL Abstract This experiment compared specific protein sequences affected by the misediting  of  ADAR  which then  resulted in specific misalignments on the protein’s structure and folding. The information was analyzed for relationships between different mutations to help regulate genes and prevent diseases such as ALS, leukemia, and schizophrenia related to the misediting  of the ADAR protein. The sequences of the GluA2 Isoforms, PTPN6 protein, and 5-HT(2C) protein were […]

Zika Virus: Novel Detection Techniques and Treatment

Abstract The United States is one of the countries affected by this disease, which cause microcephaly in newborns. In order to stop the spread, new novel detection techniques were developed such as RT-Lamp and the RT-PCR and treatments as Emricasan, Niclosamide and CDK, these drugs can help prevent Zika virus duplication. Therefore, with these new advancements in technology and medicine the Zika will have a much slimmer chance of creating chaos in today’s society. Introduction […]

On the Development of Q. alba as an Oral Care Product: A Comparison with T. chebula by TLC

Tejas Thvar Mountain View High School, Mountain View, CA Abstract Natural remedies for oral care have been used since ancient times.  The fruit of Terminalia Chebula (T. chebula), a tropical deciduous tree, has been widely used in oral care in tropical countries. In more recent studies the antimicrobial and antibacterial properties of T. chebula have been adequately demonstrated. T. chebula, however, grows only in specific locations in South Asia and not easily available in other […]