Mela-NO-More: Fighting Cancer with Immunotherapy

Author:¬†Anika Markan Introduction: In 2017, approximately 87,110 new cases of ¬†melanoma will be diagnosed and about 9,730 people are expected to die of melanoma. For the past 30 years, the rates of melanoma have been rising (Key Statistics for Melanoma Skin Cancer 1). There are many new treatments being discovered to treat melanoma everyday. Among the most common cancer treatments are chemotherapy, radiation therapy, and surgery. Chemotherapy is a systemic therapy that targets growing cancer […]

A Novel Computational Genetics Framework for Identifying New Candidate Circulating Biomarkers of Heart Failure

Avanika Narayan Palo Alto Senior High School - Palo Alto, Ca Acknowledgments My sincere and heartfelt thanks to Dr. Euan Ashley for giving me the opportunity to perform research at the Falk Cardiovascular Center in Stanford University. I thank him for providing insight and direction to my research interests. I am grateful to Daryl Waggott, my primary mentor, who has been a constant pillar of support throughout this incredible experience. Daryl was always eager and […]

Customized Chemotherapy Regime Based on Blood Vessels with Different Number of Stenosis

  Yifan Wang 1, Will Cao 2 1 Indian Springs School, 190 Woodward Drive, Indian Springs, AL 35124, USA E-mail: yifan.wang@indiansprings.org 2 Department of Biomedical Engineering, Duke University, Durham, NC 27705, USA Email: yangxiaolu.cao@duke.edu Abstract Chemotherapy has been an effective approach to treat cancer; however, chemotherapy's effectiveness could be influenced by many unknown and often neglected factors. In this project, we build mathematical models in MATLAB to explain what impact will blood vessel with stenosis […]

Development of a Small Molecule C-X-C Chemokine Receptor Type 4 (CXCR4) Agonist

Authorship: Tiffany Ding*, Susriya Gangireddy*, Andrew Shum, Richard J. Miller** *These authors contributed equally **Corresponding author: r-miller10@northwestern.edu Student: Illinois Math and Science Academy, 1500 Sullivan Road, Aurora, IL Mentor: Northwestern University-Feinberg School of Medicine, 645 N Michigan Avenue, Suite 900, Chicago, IL Abstract: Activation of the C-X-C chemokine receptor type 4 (CXCR4) by its natural ligand stromal cell-derived factor 1 (SDF-1) is known to be involved in a number of vital physiological processes such as […]

Role of Telomeres in Aging

HoJun Kweon* and HyoJu Kweon Daegu International School, 101-dong 2201-ho, 10, Palgong-ro 53-gil, Dong-gu, Daegu, Republic of Korea Jinkyoung (May) Lee Yongsan International School of Seoul, San 10-213, Hannam 2 dong, Yongsan-ku, Seoul, Republic of Korea Abstract At the ends of eukaryotic chromosomes are telomeres, which play a central role in the protection of genetic data and the enabling of cell division. Telomeres modify the cellular response to growth and stress based on various hereditary […]