The Effect of Exercise on Regulatory T Cell Populations in Rat Mammary Adenocarcinoma Tumor and Spleen Samples using Foxp3 and CD25

The Effect of Exercise on Regulatory T Cell Populations in Rat Mammary Adenocarcinoma Tumor and Spleen Samples using Foxp3 and CD25 Sharonya Battula ABSTRACT In healthy individuals, regulatory T cells (Tregs) suppress self-reactive lymphocytes to prevent autoimmune disease; however, in cancer patients, Tregs also serve a protumorigenic function, as their presence in the tumor microenvironment interferes with the ability of other lymphocytes to target and eliminate cancer cells. Because the progression of cancer is largely […]

Combined efficiency of preloaded beta-galactosidase and ultra-filtration in the production of lactose-free milk products

Combined efficiency of preloaded beta-galactosidase and ultra-filtration in the production of lactose-free milk products Author: Bryn Werley Abstract: Lactose intolerance is a condition which results in the inability to digest lactose, a disaccharide naturally found in milk. Lactose intolerance is caused by a deficiency in beta-galactosidase (lactase) enzyme production.  This results in a lack of lactose hydrolyzation during digestion. A lactase-deficient individual will experience gastrointestinal distress upon consumption of lactose. Lactose-free milk products are manufactured by preloading […]

Investigating ALS Associated Mutations on the FUS Gene

Investigating ALS Associated Mutations on the FUS Gene Author: Eesha Verma   Abstract In the Fused in Sarcoma (FUS) protein, amyotrophic lateral sclerosis (ALS) linked mutations cluster in the C-terminal nuclear localization sequence (NLS), a domain that binds to transportin- 1 (TNPO1) for import of FUS into the nucleus. This project was conducted to gain a better understanding of the structural and functional effects of mutations in the NLS domain. It was hypothesized that the […]

Detection of the KIT D816V gene mutation using chip-based Digital PCR Technology

Detection of the KIT D816V gene mutation using chip-based Digital PCR Technology Michelle Mai Century High School Rochester, MN 55906 Abstract The single point mutation of KIT D816V is the common genetic mutation of Systemic Mastocytosis (SM) and other cancers such as Acute Myelogenous Leukemia (AML) and gastrointestinal stromal tumors. Real-time allele-specific relative quantification is a common technique for detecting mutant allele vs. wild-type allele despite having well-known limitations. Examples of limitations include an inability […]