Examining the Effect of TRIP13 Over Expression on Cancerous Aneuploidy

        This Research was completed with the University of Toledo Sanjay Jinka Anthony Wayne High School 2801 W Bancroft St, Toledo, OH 43606 ABSTRACT Nineteen million people are projected to have cancer by 2024 so understanding tumorigenesis is of foremost importance. Of solid tumors, 90 percent are aneuploid, signifying an abnormal number of chromosomes usually caused by malfunctioning mitotic checkpoints. TRIP13 AAA-ATPase is a crucial silencing protein in this checkpoint. Therefore, it was hypothesized that TRIP13 […]

Secondary Structure Changes caused by ADAR Protein in the Development of ALS, Leukemia, and Schizophrenia

By Kavya Anjur Metea Valley High School, IL Abstract This experiment compared specific protein sequences affected by the misediting  of  ADAR  which then  resulted in specific misalignments on the protein’s structure and folding. The information was analyzed for relationships between different mutations to help regulate genes and prevent diseases such as ALS, leukemia, and schizophrenia related to the misediting  of the ADAR protein. The sequences of the GluA2 Isoforms, PTPN6 protein, and 5-HT(2C) protein were […]

On the Development of Q. alba as an Oral Care Product: A Comparison with T. chebula by TLC

Tejas Thvar Mountain View High School, Mountain View, CA Abstract Natural remedies for oral care have been used since ancient times.  The fruit of Terminalia Chebula (T. chebula), a tropical deciduous tree, has been widely used in oral care in tropical countries. In more recent studies the antimicrobial and antibacterial properties of T. chebula have been adequately demonstrated. T. chebula, however, grows only in specific locations in South Asia and not easily available in other […]

Lipopolysaccharide-Induced Acute Inflammation in Mouse Lung

Lipopolysaccharide-Induced Acute Inflammation in Mouse Lung Robert Xiaxuan Lao Mentor: Professor Hartmut Grasemann, MD 1.0 Abstract 1.1 Rationale Lipopolysaccharides (LPS) from gram-negative bacteria have the ability to induce immune responses in humans. The presence of cells, such as macrophages and neutrophils, as well as production of nitric oxide (NO) is increased in such circumstances. We studied the effects that LPS has on pulmonary function in mice, to serve as a basis for future implementations of […]