Examining the Effects of Progesterone of Neonatal Traumatic Brain Injury

Alexis Schneider Upper Dublin High School   Abstract   Background: Traumatic brain injury (TBI) is a major issue in young children with current treatment limited to rest. TBI’s negative health effects may be mitigated by decreasing associated inflammation.  Progesterone is a hormone with potential to decrease inflammation.   Microglia are brain macrophages that mediate inflammation and express Iba1 and ED1 proteins during active inflammation.  Injured axons express APP. By targeting ED1, Iba1, and APP through immunohistochemistry, […]

Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]

A Three Year Study of an Isolated Brook Trout Population in the Eastern Adirondacks: Sustainability, Propagation and Genetics

Over the past several years changing weather patterns have led to costly and destructive storms that are damaging both environmentally and economically. In 2011, Hurricane Irene was an unusual storm because it struck the eastern Adirondack Mountains in New York. The Adirondack region mainly relies on tourists to make money and fishing is a large part of what draws people to this region. Three years ago, a study was started to explore the impact of […]

Alcoholism: A Neurological Perspective

After an intensive course regarding alcoholism with Dana Most and Dr. Adron Harris in the Waggoner Center for Alcohol and Addiction Research at the University of Texas at Austin, alcoholism, its causes, diagnosis, prognosis, and FDA-approved treatments were investigated. Here is the report written under their guidance. Alcoholism is one of the foremost problems in society today. The DSM-5 manual helps doctors tell what disease you may have and better allows them to treat you […]