Ondansetron: A Breakthrough in Pharmaceutical Research

Nausea and vomiting are fairly common symptoms resulting in emergency room visits and in hospitalization. Some common medical conditions that result in these symptoms include “Gastroenteritis (food poisoning), pregnancy, complication of chemotherapy in cancer patients, and major surgical procedures” ((Cortina-Borja M, et al. (2010) Prenatal Treatment for Serious Neurological Sequelae of Congenital Toxoplasmosis: An Observational Prospective Cohort Study. Plos Med. Oct 12;(7)(10) )). Ondansetron is the most effective anti-vomiting drug available today. It is available […]

The Nutty Truth

Nuts? No thanks, many regretfully say while clearly tempted. Nuts, after all, get more than half of their calories from fat and are notoriously known for being high in fat. Nuts have a greater ratio of fat calories than whole milk, ground beef, and even cheese have. Nutritionists have warned in the past that nuts are a dangerous food item; nuts not only will cause one to gain weight but they will also increase one's […]

Composite Gold-Silver Alloy Nanoparticles for GFP Interactions

A PDF version of this paper is available here. Abstract: Gold nanoparticles (AuNPs) are widely used for their optical sensitivity and convenience. The unique optical properties of AuNPs arise from their surface plasmon resonance (SPR) when interacting with light of various wavelengths in the visible range. We are developing a novel gold and silver composite nanoparticle (AuAg-NP) with tunable optical properties, synthesized by reduction of AgNO3 and HAuCl4 with oleylamine and octadecene as reducing agents. […]

Identifying New Inhibitors of the Human Metalloprotease Meprin A

A PDF version of this paper is available here. Thumbnail image: Structure of Concanavalin A Abstract: This research is focused on finding an effective inhibitor of human Meprin A, which may have therapeutic potential. Meprin A is known to be inhibited by ethylene diamine tetraacetate (EDTA) and actinonine ((Bylander J,  Bertenshaw G,  Matters G,  Hubbard S, and  Bond JS. Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. J. Biol. Chem.. 388:1163-1172 (2007).)), […]

Antibacterial and Antifungal Properties of Turmeric

Editor's note: Though the NHSJS usually features work by high schoolers, it occasionally gets the chance to showcase extraordinary research done by young scientists across the country. This project was done by a student in third grade - we hope you enjoy it. Introduction: The project investigates whether the external application of turmeric reduces the growth of fungi and bacteria in foods. Background: Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae. […]