Identifying New Inhibitors of the Human Metalloprotease Meprin A

A PDF version of this paper is available here. Thumbnail image: Structure of Concanavalin A Abstract: This research is focused on finding an effective inhibitor of human Meprin A, which may have therapeutic potential. Meprin A is known to be inhibited by ethylene diamine tetraacetate (EDTA) and actinonine ((Bylander J,  Bertenshaw G,  Matters G,  Hubbard S, and  Bond JS. Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities. J. Biol. Chem.. 388:1163-1172 (2007).)), […]