Unraveling Alzheimer's: The Effects of Tau on AB Protein Aggregation

Abstract Alzheimer’s is a neurodegenerative disease characterized by the formation of extracellular amyloid-beta (abeta or AB) plaques and intracellular tau plaques. This experiment explores whether the presence of normal tau-441 protein augments AB-42 aggregation. The concentration at which each protein self-aggregated was identified by creating aggregation curves. A control and experimental aliquot of AB/buffer and AB/tau respectively were then scanned at regular intervals to determine the rate amount of aggregation in each. The conclusion is […]