Development of a Small Molecule C-X-C Chemokine Receptor Type 4 (CXCR4) Agonist

Authorship: Tiffany Ding*, Susriya Gangireddy*, Andrew Shum, Richard J. Miller** *These authors contributed equally **Corresponding author: r-miller10@northwestern.edu Student: Illinois Math and Science Academy, 1500 Sullivan Road, Aurora, IL Mentor: Northwestern University-Feinberg School of Medicine, 645 N Michigan Avenue, Suite 900, Chicago, IL Abstract: Activation of the C-X-C chemokine receptor type 4 (CXCR4) by its natural ligand stromal cell-derived factor 1 (SDF-1) is known to be involved in a number of vital physiological processes such as […]

The Imperative Need to Consider the Bioethics of CRISPR-Cas9 Technology

  Jihee Yoon University High School, CA   Abstract The CRISPR-Cas9 technology is the latest and most controversial gene editing technology available today. It allows for precise editing of DNA, which is also known as the genetic code of the human body. While CRISPR seems to possess great potential to solve genetic mutations, ethicists and researchers still believe this technology should not be applied as of now due to its insufficient experimentation, significant consent limitations, […]

Secondary Structure Changes caused by ADAR Protein in the Development of ALS, Leukemia, and Schizophrenia

By Kavya Anjur Metea Valley High School, IL Abstract This experiment compared specific protein sequences affected by the misediting  of  ADAR  which then  resulted in specific misalignments on the protein’s structure and folding. The information was analyzed for relationships between different mutations to help regulate genes and prevent diseases such as ALS, leukemia, and schizophrenia related to the misediting  of the ADAR protein. The sequences of the GluA2 Isoforms, PTPN6 protein, and 5-HT(2C) protein were […]

On the Development of Q. alba as an Oral Care Product: A Comparison with T. chebula by TLC

Tejas Thvar Mountain View High School, Mountain View, CA Abstract Natural remedies for oral care have been used since ancient times.  The fruit of Terminalia Chebula (T. chebula), a tropical deciduous tree, has been widely used in oral care in tropical countries. In more recent studies the antimicrobial and antibacterial properties of T. chebula have been adequately demonstrated. T. chebula, however, grows only in specific locations in South Asia and not easily available in other […]