Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]

A Three Year Study of an Isolated Brook Trout Population in the Eastern Adirondacks: Sustainability, Propagation and Genetics

Over the past several years changing weather patterns have led to costly and destructive storms that are damaging both environmentally and economically. In 2011, Hurricane Irene was an unusual storm because it struck the eastern Adirondack Mountains in New York. The Adirondack region mainly relies on tourists to make money and fishing is a large part of what draws people to this region. Three years ago, a study was started to explore the impact of […]

Alcoholism: A Neurological Perspective

After an intensive course regarding alcoholism with Dana Most and Dr. Adron Harris in the Waggoner Center for Alcohol and Addiction Research at the University of Texas at Austin, alcoholism, its causes, diagnosis, prognosis, and FDA-approved treatments were investigated. Here is the report written under their guidance. Alcoholism is one of the foremost problems in society today. The DSM-5 manual helps doctors tell what disease you may have and better allows them to treat you […]

Development of a Small Molecule C-X-C Chemokine Receptor Type 4 (CXCR4) Agonist

Authorship: Tiffany Ding*, Susriya Gangireddy*, Andrew Shum, Richard J. Miller** *These authors contributed equally **Corresponding author: r-miller10@northwestern.edu Student: Illinois Math and Science Academy, 1500 Sullivan Road, Aurora, IL Mentor: Northwestern University-Feinberg School of Medicine, 645 N Michigan Avenue, Suite 900, Chicago, IL Abstract: Activation of the C-X-C chemokine receptor type 4 (CXCR4) by its natural ligand stromal cell-derived factor 1 (SDF-1) is known to be involved in a number of vital physiological processes such as […]

Role of Telomeres in Aging

HoJun Kweon* and HyoJu Kweon Daegu International School, 101-dong 2201-ho, 10, Palgong-ro 53-gil, Dong-gu, Daegu, Republic of Korea Jinkyoung (May) Lee Yongsan International School of Seoul, San 10-213, Hannam 2 dong, Yongsan-ku, Seoul, Republic of Korea Abstract At the ends of eukaryotic chromosomes are telomeres, which play a central role in the protection of genetic data and the enabling of cell division. Telomeres modify the cellular response to growth and stress based on various hereditary […]

Facilitating Biodigester Biogas Production Using a Rumination Model of Bos taurus

Abstract In order to develop resource and time efficient methods of biogas production as an energy source, the biodigestion procedure physically and chemically modified the biodigestion process to mimic the rumination process of Bos taurus. The experimental protocol used manure slurry and the independent variables of a varying mixing times and digestive enzymes to produce biogases. The results demonstrated significant increases in biogas production with both mixing time variation and enzyme additives to manure slurry. […]

The Effect of Nitrogen on Invasive Plant Species

Zachary J. Duthie Upper Dublin High School Class of 2019 pduthie1@gmail.com   Table of Contents Abstract …………………………………………………… 3 Problem …………………………………………………… 3 Introduction …………………………………………………… 3 Hypothesis …………………………………………………… 5 Methods …………………………………………………… 5 Results …………………………………………………… 6 Analysis …………………………………………………… 6 Conclusion …………………………………………………… 7 Bibliography …………………………………………………… 9 Abstract Progress in farming and industry has yielded great benefits to mankind, but activities associated with this progress have increased nitrogen levels in the soil  (Vitousek, 1997).  This experiment was conducted to test […]