Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]

A Three Year Study of an Isolated Brook Trout Population in the Eastern Adirondacks: Sustainability, Propagation and Genetics

Over the past several years changing weather patterns have led to costly and destructive storms that are damaging both environmentally and economically. In 2011, Hurricane Irene was an unusual storm because it struck the eastern Adirondack Mountains in New York. The Adirondack region mainly relies on tourists to make money and fishing is a large part of what draws people to this region. Three years ago, a study was started to explore the impact of […]

Alcoholism: A Neurological Perspective

After an intensive course regarding alcoholism with Dana Most and Dr. Adron Harris in the Waggoner Center for Alcohol and Addiction Research at the University of Texas at Austin, alcoholism, its causes, diagnosis, prognosis, and FDA-approved treatments were investigated. Here is the report written under their guidance. Alcoholism is one of the foremost problems in society today. The DSM-5 manual helps doctors tell what disease you may have and better allows them to treat you […]

Beyond the Edges of the Universe

By Palak Porwal In our everyday lives, we have often heard that the ‘universe is expanding’. But have we ever thought about what is the universe expanding into or where exactly is it expanding? Even if we acquire far better telescopes than we use today it will be challenging to explore the edges of our observable universe, because we are limited to information brought to us by light travelling from far off distances. Many physicist […]

A Novel Computational Genetics Framework for Identifying New Candidate Circulating Biomarkers of Heart Failure

Avanika Narayan Palo Alto Senior High School - Palo Alto, Ca Acknowledgments My sincere and heartfelt thanks to Dr. Euan Ashley for giving me the opportunity to perform research at the Falk Cardiovascular Center in Stanford University. I thank him for providing insight and direction to my research interests. I am grateful to Daryl Waggott, my primary mentor, who has been a constant pillar of support throughout this incredible experience. Daryl was always eager and […]

Gene Therapy for Sensorineural Hearing Loss

By Eshaan Soman Abstract Sensorineural hearing loss is a serious impairment that deprives more than 360 million people worldwide from one of their vital senses. Furthermore, more than 1.1 billion people are becoming increasingly susceptible to the condition as well (“Deafness and Hearing Loss”). Though common, this medical disability has no cure yet. However, gene therapy is an emerging treatment that is being developed to tackle the root causes of this morbidity. Introduction Humans interpret […]

Comprehensive Review of Exchange-Correlation Functional Methods

Ashwin Inala NCSSM Online North Carolina School of Science and Mathematics Durham, North Carolina February 25, 2017 Abstract: Density functional theory is a computational technique of using elec- tron density, not wavefunction, to predict properties of molecular systems. Over the years, many scientists, such as Pierre Hohenberg, Erwin Schrodinger, and Walter Kohn, have contributed to the fast growth of density functional theory. To find the energy of system, scientists must approximate the exchange-correlation functional. The […]

Progression Towards A Universal Communication Technology

Introduction All throughout the history of mankind, there has been an eternal human desire to communicate.  This thirst for improvement did not discriminate; it manifested itself in every human civilization. No matter what artificial divisions were imposed on people, this force bound everyone together in the pursuit of a common goal. The purpose of this paper is to identify what communication technology is truly universal. This technology would then achieve this common goal of all […]