Computational Analysis of Drug Therapy Options for Glioblastoma

Kriti Agrawal Centerville High School Abstract Glioblastoma (GBM) is the most common primary brain tumor in the US and European countries and also the deadliest.  Glioblastoma cells exhibit a different gene expression profile from normal cells. There are 601 known mutations in GBM tumors. The aim of this study was to identify the most important proteins in the glioblastoma pathway that lack drug treatments. A total of 15 proteins were identified as pathway starters or […]

A Three Year Study of an Isolated Brook Trout Population in the Eastern Adirondacks: Sustainability, Propagation and Genetics

Over the past several years changing weather patterns have led to costly and destructive storms that are damaging both environmentally and economically. In 2011, Hurricane Irene was an unusual storm because it struck the eastern Adirondack Mountains in New York. The Adirondack region mainly relies on tourists to make money and fishing is a large part of what draws people to this region. Three years ago, a study was started to explore the impact of […]

Alcoholism: A Neurological Perspective

After an intensive course regarding alcoholism with Dana Most and Dr. Adron Harris in the Waggoner Center for Alcohol and Addiction Research at the University of Texas at Austin, alcoholism, its causes, diagnosis, prognosis, and FDA-approved treatments were investigated. Here is the report written under their guidance. Alcoholism is one of the foremost problems in society today. The DSM-5 manual helps doctors tell what disease you may have and better allows them to treat you […]

An Evaluation of Anti-Depressants Versus Non-Medication Therapies on the Treatment of Depressive Disorders

By Divya Manikandan Ever since the late 1900’s and straight into the 21st century, we have witnessed an increased marketing and usage of anti-depressants by the general population , with SSRI’s (selective serotonin reuptake inhibitors) such a Prozac, becoming household names. However, while these drugs may have their positives, their negative patho-physiological side effects remain largely undermined. This article aims to create an in depth analysis of the biological impact of various Anti-Depressant drugs in […]

Mela-NO-More: Fighting Cancer with Immunotherapy

Author: Anika Markan Introduction: In 2017, approximately 87,110 new cases of  melanoma will be diagnosed and about 9,730 people are expected to die of melanoma. For the past 30 years, the rates of melanoma have been rising (Key Statistics for Melanoma Skin Cancer 1). There are many new treatments being discovered to treat melanoma everyday. Among the most common cancer treatments are chemotherapy, radiation therapy, and surgery. Chemotherapy is a systemic therapy that targets growing cancer […]

Beyond the Edges of the Universe

By Palak Porwal In our everyday lives, we have often heard that the ‘universe is expanding’. But have we ever thought about what is the universe expanding into or where exactly is it expanding? Even if we acquire far better telescopes than we use today it will be challenging to explore the edges of our observable universe, because we are limited to information brought to us by light travelling from far off distances. Many physicist […]

A Novel Computational Genetics Framework for Identifying New Candidate Circulating Biomarkers of Heart Failure

Avanika Narayan Palo Alto Senior High School - Palo Alto, Ca Acknowledgments My sincere and heartfelt thanks to Dr. Euan Ashley for giving me the opportunity to perform research at the Falk Cardiovascular Center in Stanford University. I thank him for providing insight and direction to my research interests. I am grateful to Daryl Waggott, my primary mentor, who has been a constant pillar of support throughout this incredible experience. Daryl was always eager and […]

Gene Therapy for Sensorineural Hearing Loss

By Eshaan Soman Abstract Sensorineural hearing loss is a serious impairment that deprives more than 360 million people worldwide from one of their vital senses. Furthermore, more than 1.1 billion people are becoming increasingly susceptible to the condition as well (“Deafness and Hearing Loss”). Though common, this medical disability has no cure yet. However, gene therapy is an emerging treatment that is being developed to tackle the root causes of this morbidity. Introduction Humans interpret […]