Investigating ALS Associated Mutations on the FUS Gene

Investigating ALS Associated Mutations on the FUS Gene Author: Eesha Verma   Abstract In the Fused in Sarcoma (FUS) protein, amyotrophic lateral sclerosis (ALS) linked mutations cluster in the C-terminal nuclear localization sequence (NLS), a domain that binds to transportin- 1 (TNPO1) for import of FUS into the nucleus. This project was conducted to gain a better understanding of the structural and functional effects of mutations in the NLS domain. It was hypothesized that the […]

The Effects of Virtual Reality on Learning

The Effects of Virtual Reality on Learning By Rohit Mehta ABSTRACT Virtual reality is a highly effective and unique complement to traditional learning methods, bringing with it solutions to common problems such as excessive reliance on certain ways of learning, the inefficacy of current attempts to include visual elements of learning in education, and the lack of appeal to students. I demonstrate how the introduction of virtual reality in a classroom setting can positively impact […]

Detection of the KIT D816V gene mutation using chip-based Digital PCR Technology

Detection of the KIT D816V gene mutation using chip-based Digital PCR Technology Michelle Mai Century High School Rochester, MN 55906 Abstract The single point mutation of KIT D816V is the common genetic mutation of Systemic Mastocytosis (SM) and other cancers such as Acute Myelogenous Leukemia (AML) and gastrointestinal stromal tumors. Real-time allele-specific relative quantification is a common technique for detecting mutant allele vs. wild-type allele despite having well-known limitations. Examples of limitations include an inability […]

Expansion Measurement of the Edge Velocity of the Bubble Nebula (NGC 7635)

Expansion Measurement of the Edge Velocity of the Bubble Nebula (NGC 7635) Authors: Clyde Xu: The Hill School, Pottstown, PA; Fritz Ruppert: Brevard High School, Breard, NC; Juan Hernandez: Alamo Heights High School, San Antonio, TX   Abstract: In comparison to other nebulae, the Bubble Nebula certainly has not received much attention. Not enough detailed research has been conducted on the nebula and therefore more data are needed to have a comprehensive understanding of the nebula. According […]

Effects of Nitro-Oleic Acid on RAW-Blue™ Cell Activity

by David J Portnoy Abstract Chronic inflammatory disease affects millions of individuals around the world. Inflammation occurs when foreign bacteria bind to receptors on cell surfaces, thereby inducing macrophage activation. This series of actions leads to the release of pro-inflammatory molecules, like nitric oxide (NO), resulting in inflammation. A major driver of inflammatory responses is the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB). This study seeks to examine the interaction between OA-NO2 […]